Chiral α ‐Amino Acid‐Based NMR Solvating Agents
نویسندگان
چکیده
منابع مشابه
Differentiation of chiral phosphorus enantiomers by P and H NMR spectroscopy using amino acid derivatives as chemical solvating agents.
The ability of commercially available amino acid derivatives, especially Fmoc-Trp(Boc)-OH, to differentiate enantiomers of chiral phosphonates, phosphinates, phosphates, phosphine oxides, and phosphonamidates is demonstrated with (31)P, (13)C, and (1)H NMR spectroscopy. The chiral differentiation provided a rapid and convenient method for measuring the enantiomeric purity of these phosphorus co...
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The utility of phosphated α-, β- and γ-cyclodextrins as water-soluble chiral NMR solvating agents for cationic substrates is described. Two sets of phosphated cyclodextrins, one with degrees of substitution in the 2-6 range, the other with degrees of substitution in the 6-10 range, are examined. Results with 33 water-soluble cationic substrates are reported. We also explored the possibility tha...
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The use of NMR chiral solvating agents (CSAs) for the analysis of enantiopurity has been known for decades, but has been supplanted in recent years by chromatographic enantioseparation technology. While chromatographic methods for the analysis of enantiopurity are now commonplace and easy to implement, there are still individual compounds and entire classes of analytes where enantioseparation c...
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We report a special, hitherto-unexplored property of (-)-epigallocatechin gallate (EGCG) as a chiral solvating agent for enantiodiscrimination of α-amino acids in the polar solvent DMSO. This phenomenon has been investigated by (1)H NMR spectroscopy. The mechanism of the interaction property of EGCG with α-amino acids has been understood as arising out of hydrogen-bonded noncovalent interaction...
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ژورنال
عنوان ژورنال: Helvetica Chimica Acta
سال: 2020
ISSN: 0018-019X,1522-2675
DOI: 10.1002/hlca.202000081